What is it about?

This research paper presents findings from the FIDELITY analysis, which pools data from two significant studies, FIDELIO-DKD and FIGARO-DKD, involving over 13,000 participants with type 2 diabetes and chronic kidney disease (CKD). The study's aim was to evaluate the effectiveness and safety of finerenone, a novel non-steroidal mineralocorticoid receptor antagonist, in reducing cardiovascular and kidney-related outcomes. The participants, who were already on a regimen including the maximum tolerated dose of renin–angiotensin system inhibitors, were observed for a median follow-up period of three years. The results demonstrated that finerenone significantly reduced the incidence of major cardiovascular events and progression to kidney failure compared to placebo.

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Why is it important?

This study is pivotal for several reasons. Firstly, it addresses a critical gap in the treatment of patients with type 2 diabetes and CKD, who are at high risk of cardiovascular morbidity and kidney failure. By demonstrating that finerenone can significantly reduce these risks, the study offers hope for improving patient outcomes and quality of life. Secondly, the comprehensive data set from the pooled analysis provides robust evidence of finerenone's benefits across a broad spectrum of CKD stages. Lastly, the findings support the use of finerenone as a valuable addition to standard care, potentially setting a new standard in the management of CKD in patients with type 2 diabetes. Key takeaways: 1. Finerenone reduces major cardiovascular events and kidney failure risks. 2. Offers new hope for patients with type 2 diabetes and CKD. 3. Supports finerenone's inclusion in standard CKD management protocols.

Read the Original

This page is a summary of: Cardiovascular and kidney outcomes with finerenone in patients with type 2 diabetes and chronic kidney disease: the FIDELITY pooled analysis, European Heart Journal, November 2021, Oxford University Press (OUP),
DOI: 10.1093/eurheartj/ehab777.
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