What is it about?

To evaluate the natural background of prostate cancer in Iran a large population-based study of screening using total prostate-specific antigen (tPSA) and per cent free PSA (fPSA) as the initial test was performed.

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Why is it important?

The distribution of cancers varies significantly from country to country all over the world. The latest estimates of global cancer incidence show that prostate cancer is the sixth most common cancer in the world (in the number of new cases), the third most common cancer in men, the most common cancer in men in Europe, North America, and some parts of Africa with half a million new cases each year, almost 10% of all cancers in men.


Prostate cancer screening using PSA testing is peculiar among screening interventions, because it is widely adopted in Western countries. PSA is a valid screening test for prostate cancer, which compares favorably with mammography for breast cancer.

Dr Mohammad Reza Safarinejad
University of Medical Sceices

Read the Original

This page is a summary of: Population-based screening for prostate cancer by measuring free and total serum prostate-specific antigen in Iran, Annals of Oncology, May 2006, Oxford University Press (OUP),
DOI: 10.1093/annonc/mdl087.
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