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Using both 2-D and 3-D culture methods we showed that a triple negative breast cancer cell line that is highly metastatic to bone (MDA-MB-231) migrates toward bone only if marrow is present. Analyzing proteins in the media and verifying with transwell studies, we showed that leptin is an important chemokine in this process. Cancer cells may use adipocytes, which secrete leptin, as a target to home to a favorable niche.
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This page is a summary of: The effect of marrow secretome and culture environment on the rate of metastatic breast cancer cell migration in two and three dimensions, Molecular Biology of the Cell, May 2021, American Society for Cell Biology (ASCB),
DOI: 10.1091/mbc.e19-12-0682.
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