Synthesis of Some New Fluorine Containing Thiadiazolotriazinones as Potential Antibacterial Agents

  • B. Shivarama Holla, K. Subrahmanya Bhat, N. Suchetha Shetty
  • Phosphorus Sulfur and Silicon and the Related Elements, October 2003, Taylor & Francis
  • DOI: 10.1080/713744567

Novel compounds, not much scope as antibacterial agents, but can explore in material science

What is it about?

2,4-dichloro-5-fluorophenyl, 4-fluoro-3-(Phenoxy)phenyl, 4-fluorophen-yl groups are known pharmacophores and can be used in the synthesis of new biologically active molecules. Therefore, 4-amino-6-arylmethyl-3-mercapto-1,2,4-triazin5(4H)-ones 1 are condensed with 3-phenoxy-4-fluoro-benzoic acid, 2,4-dichloro-5-fluorobenzoic acid, and 4-fluorobenzoic acid 2 to give 7-substituted-3-arylmethyl-4H-1,3,4-thiadiazolo[2,3-c]-1,2,4-triazin-4-ones 3 . Phosphorous oxychloride was used as cyclizing agent. All the newly synthesized compounds 3a-l was screened for their antibacterial activities. Most of them showed promising activity in the range of 10 w g/mL concentrations.

Why is it important?

Modest antimicrobial properties of the compounds were reported.


Dr Subrahmanya Bhat K
Manipal Institute Of Technology, Manipal Academy of Higher Education

There is a scope to further derivatize and test newer compounds.

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The following have contributed to this page: Dr Subrahmanya Bhat K