The function of the HBeAg is substantially known and should be acknowledged

What is it about?

The secreted HBeAg functions as an immunomodulatory protein , which may also elicit immune tolerance in utero and/or during perinatal infection. This article reviews the human and animal model data which substantiates this interpretation.

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Why is it important?

The function of the HBeAg is often referred to as " unknown ". This article counters this opinion by listing the evidence that indicates that the function of the HBeAg is indeed known. The HBeAg as well as the HBsAg are secreted proteins that act as immune modifiers , which down regulate the immune response and can effect viral clearance.