What is it about?
Infiltration of tumor tissues by immune cells is limited by their compact structure. We have shown that it is possible to genetically engineer immune cells to enhance their ability to move through any tumor. In this article we show that heparanase, an enzyme that partially degrades the matrix that maintain the cohesion of the tumor tissues,
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Why is it important?
Facilitating the access of immune cells to tumors allows the development of improved immunotherapy options for cancer patients.
Perspectives
Further research is required to demonstrate that this strategy can be applied in the treatment of cancer patients.
Dr Angel Cid Arregui
Asteriapharma
Read the Original
This page is a summary of: An integral membrane constitutively active heparanase enhances the tumor infiltration capability of NK cells, OncoImmunology, December 2024, Taylor & Francis,
DOI: 10.1080/2162402x.2024.2437917.
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