New concept in Immunology

What is it about?

This paper describes for the first time the capacity of non professional Antigen Presenting Cells (APC), such as tumor cells of epithelial origin, to serve as professional APC for their own tumor antigens and, more importantly, to prime naive vergin T cells to become anti-tumor effectors

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Why is it important?

This work discloses the possibility of using CIITA-modified tumor cells as a potent vaccine against a wide variety of cancers