What is it about?
Our paper is about the molecular nature of yeast prions and their variants. We demonstrate that any prion variant is a hereditary factor of double molecular nature: its properties are determined not only by the state of the prion protein but also by a DNA sequence encoding this protein.
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Why is it important?
Our paper opens a novel view at non-canonical (epigenetic) hereditary factors. Unlike canonical (DNA-only) hereditary factors, these are of double molecular nature. Any non-canonical hereditary factor is represented by (i) a specific DNA sequence and (ii) specific epigenetic marks associated either with this sequence or with its product (RNA or protein).
Perspectives
Our work allows the development of modern genetic theories equally covering all kinds of hereditary factors, whether canonical or not (see Tikhodeyev, 2018. The mechanisms of epigenetic inheritance: How diverse are they? Bilogical Reviews, 93: 1987-2005; Tikhodeyev, 2022. Prions as non-canonical hereditary factors. Russian Journal of Genetics, 58: 626-637).
Oleg Tikhodeyev
Saint Petersburg State University
Read the Original
This page is a summary of: Allelic variants of hereditary prions: The bimodularity principle, Prion, January 2017, Taylor & Francis,
DOI: 10.1080/19336896.2017.1283463.
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