Deciphering the transcription factor-microRNA-target gene regulatory network associated with graphene oxide cytotoxicity

Masoumeh Farahani, Mostafa Rezaei–Tavirani, Hakimeh Zali, Afsaneh Arefi Oskouie, Meisam Omidi, Alireza Lashay
  • Nanotoxicology, October 2018, Taylor & Francis
  • DOI: 10.1080/17435390.2018.1513090

microRNA-graphene oxide interactions: specific toxic effects of graphene oxide in cancer therapy

What is it about?

The gene regulatory network-based approach provides detailed features of the molecular mechanisms and related pathways in responding to graphene oxide treatment.

Why is it important?

The toxicity of nanoparticles has a considerable impact on the levels and functions of miRNAs. The specific toxic properties via microRNA-graphene oxide interactions support biomedical applications of graphene oxide in cancer therapy.

Perspectives

Masoumeh Farahani
shahid beheshti university of medical sciences

The importance of miRNAs in cancer biology as therapeutic targets, and through regulation of their target genes, suggests further investigations on the interplay between graphene oxide and miRNAs using systems biology and pathway based approaches.

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http://dx.doi.org/10.1080/17435390.2018.1513090

The following have contributed to this page: Mostafa Rezaei Tavirani, Dr. meisam omidi, Alireza Lashay, and Masoumeh Farahani