What is it about?
Pendrin has a dual function both in iodide and chloride transport,especially is expressed in the distal tubules (functionally the most important location). As known pendrin regulates blood pressure by ionic exchanges. We hypothesized to assess the pendrin expression density in placental bed biopsies from preeclampsia cases in comparison with healthy term controls.
Featured Image
Why is it important?
Our main hypothesis was that, in preeclampsia, pendrin mediated Cl− transport in the decidua basalis should be playing a role either in the mechanisms causing maternal hypertension or in the adaptation to the hypertensive state.In our study we demonstrated the results of increased pendrin expression in early-onset preeclampsia cases. We also confirmed that increased pendrin expression was also evident in the maternal decidua.
Perspectives
At this juncture, an inquiry on the possible role for pendrin in preeclampsia, either as a player in the pathogenetic process and adaptational mechanisms or as a target for novel antihypertensive agents. In our study, we aimed to take it a step further, first by designing a prospective and larger scale case-control study on the possible association between pendrin expression status and preeclampsia.
Ali Taner Anuk
Read the Original
This page is a summary of: Pendrin Expression in Preeclampsia: A Prospective Immunohistochemical Staining Study on Placental Bed Biopsies, Fetal and Pediatric Pathology, September 2017, Taylor & Francis,
DOI: 10.1080/15513815.2017.1346016.
You can read the full text:
Contributors
The following have contributed to this page
