What is it about?
Tumor is an organ on its own. It has walls, vasculatures, fibroblasts, tumor cells and even immune cells. One way to find out what are the components of a particular tumor is to bulk analyze RNA, and look for cell type specific transcripts. Then we find amazing variety of tumor microenvironment. We classify them based on the content, and we will soon have a phylogenetic tree!
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Why is it important?
By having a phylogenetic tree, we begin to understand how cancer evolved.
Perspectives
Soon or later, all tumors become resistance to immune cell infiltration. It is a part of tumor evolution. Now we can find ways to reverse the process so that immune cells could infiltrate the tumor.
Ryuji Yamaguchi
Kansai Medical University
Read the Original
This page is a summary of: Animal models for studying tumor microenvironment (TME) and resistance to lymphocytic infiltration, Cancer Biology & Therapy, May 2018, Taylor & Francis,
DOI: 10.1080/15384047.2018.1470722.
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