What is it about?
Metabolism, transformation and dynamic changes of five alkaloids, DNJ, 2-O-α-D-Gal-DNJ, fagomine, isofagomine and 4-O-β-D-Glc-fagomine from mulberry leaves in silkworm at different instarswas observed. UPLC-Q/TOF-MS and UPLC-TQ/MS methods were adopted for qualitative analysis and quantitative analysis respectively. Mulberry leaves of three species were used to feed the silkworm as controls. By analyzing and comparing the content changes of DNJ, fagomine and their derivatives in different instars’ silkworms and silkworm excrement, we revealed the dynamic changes, confirmed the enrichment effect on the polyhydroxy alkaloids by silkworm, and inferred the conversion process behind this effect. The experimental result indicated that DNJ and its derivatives turned into some intermediate substances in the metabolic process, and finally they converted back and the content increased. Fagomine and its derivatives interconverted into each other in the process, 4-O-β-D-Glc-fagomine transformed into fagomine, while fagomine transformed into isofagomine.
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Why is it important?
This study based on previous research, by analyzing and comparing the content changes of the alkaloids in the body of different instars silkworms, researched the characteristic of the metabolic and enrichment of the alkaloids by silkworm and the components’ changes in silkworm excrement.
Perspectives
I hope this article could lays a foundation for revealing the regulation of the metabolic and enrichment, and promote further development of mulberry and silkworm resources.
liwen zhang
Nanjing University of Chinese Medicine
Read the Original
This page is a summary of: Metabolism, transformation and dynamic changes of alkaloids in silkworm during feeding mulberry leaves, Natural Product Research, June 2018, Taylor & Francis,
DOI: 10.1080/14786419.2018.1465422.
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