What is it about?
A promising amide alkaloid synthesized and tested invitro for its anticancer activity on SMMC 7721 cell lines and flow cytometry and cell cycle analysis revealed that it acts by interfering with mitochondrial pathway by activating caspase 3/9 and increasing the ratio of Bax/Bcl-2 to triger cell apoptosis and DNA damage
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Why is it important?
This compound is important for invivo biological evaluation to study for its safety and efficacy and being a synthetic one is an advantage for mass production for future use in cancer therapy.
Perspectives
Naturally sourced important chemotheraputic agents are constrained for mass production of the agent. This experiment significantly plays a role in paving the way for the possiblity of synthetic production of the agent if passed the invivo bio-evaluation. The promising chemotheraputic agent, acting on the cell cycle, gives the chance not to suffer from unwanted side effects on the patients.
Nigatu Gebrehiwot
School of Int'l Education, Department of Pharmacy Administration, Center Drug Safety Policy Research, Xian Jiaotong University
Read the Original
This page is a summary of: First total synthesis of a novel amide alkaloid derived from Aconitum taipeicum and its anticancer activity, Natural Product Research, June 2017, Taylor & Francis,
DOI: 10.1080/14786419.2017.1340283.
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