What is it about?
MADD is an autosomal recessive metabolic disorder of fatty acid metabolism. CoQ10 is used for MADD patient treatment. We showed that CoQ10 improves mitochondrial metabolic integrity and reduces lipotoxicity by decreasing oxidative stress and inflammation.
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Why is it important?
Our findings show that CoQ10 not only improves mitochondrial function but also reduces inflammasome activation and cell pyroptosis.
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This page is a summary of: Coenzyme Q10 serves to couple mitochondrial oxidative phosphorylation and fatty acid β-oxidation, and attenuates NLRP3 inflammasome activation, Free Radical Research, July 2018, Taylor & Francis,
DOI: 10.1080/10715762.2018.1500695.
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