What is it about?
This piece of work illustrates the importance of the Sirt3 protein, a deacetylase, in adipogenic differentiation through upregulating mitochondrial biogenesis and bioenergetic function of mesenchymal stem cells.
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Why is it important?
Sirt3 has been shown to play a role in the regulation of metabolism of fatty acids, which are mostly stored in adipocytes. Accumulation of fatty acids may cause insulin resistance and type 2 diabetes.
Perspectives
It will provide insights into the pathophysiology of insulin resistance and type 2 diabetes by investigating the alteration of Sirt3 levels in the adipose tissues and other peripheral tissues of these patients .
Professor and Director Yau-Huei Wei
Changhua Christian Hospital
Read the Original
This page is a summary of: Depletion of Sirt3 leads to the impairment of adipogenic differentiation and insulin resistance via interfering mitochondrial function of adipose-derived human mesenchymal stem cells, Free Radical Research, July 2018, Taylor & Francis,
DOI: 10.1080/10715762.2018.1489130.
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