What is it about?
We used a rat model of in vivo imaging of the retina - which is brain tissue and can reflect the situation at the blood-brain barrier - to study how size and surface charge determine nanoparticles’ ability to cross the blood-retina barrier.
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Why is it important?
The mechanisms of nanoparticle’s blood-brain barrier passage are still unclear and little is known about the physiochemical parameters that enable or enhance the passage. To learn more about these mechanisms and optimise nanoparticles’ delivery potential, we reasoned that varying different parameters might shed some more light on the possible mechanisms of the actions.
Perspectives
In our previous study, surfactant was found to be a critical factor determining the blood-retina barrier passage of PBCA nanoparticles; the combination of poloxamer 188 and DEAE-dextran was the most effective surfactant to enable blood-retina barrier passage. Using this specific NP design, we now systematically studied the influence of size and surface charge on blood-retina barrier passage. It seems that minor changes in design of nano-carriers can alter physicochemical parameters such as size or zeta potential, thus substantially influencing nanoparticles’ biological distribution in vivo, possibly by interactions with blood constituents and peripheral organs.
Dr. Qing You
Otto von Guericke Universitat Magdeburg
Read the Original
This page is a summary of: Major effects on blood-retina barrier passage by minor alterations in design of polybutylcyanoacrylate nanoparticles, Journal of Drug Targeting, November 2018, Taylor & Francis,
DOI: 10.1080/1061186x.2018.1531416.
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