What is it about?
Acute lymphoblastic leukemia (ALL) is one of the main causes of death in children and is associated with both genetic susceptibility and environmental factors. Genes encoding the arylamine N-acetyltransferases 1 and 2 (NAT1 and NAT2) isoenzymes are highly polymorphic among populations. Significant associations were found between the development of ALL and the presence of the haplotypes NAT1 and NAT2
Featured Image
Why is it important?
The results of this first genetic association study in Mexican pediatric patients with ALL demonstrate the NAT1 rapid haplotypes NAT1*4 and NAT1*3, as well as the NAT2 slow haplotypes NAT2*6B, NAT2*6J and NAT2*7A, are associated with the likelihood of developing ALL.
Perspectives
This study provides the basis for further research on the genetic factors that promote the development of this type of cancer
Oswaldo Hernández-González
Universidad Autonoma de San Luis Potosi
Read the Original
This page is a summary of: Genetic polymorphisms of arylamine N-acetyltransferases 1 and 2 and the likelihood of developing pediatric acute lymphoblastic leukemia, Leukemia & Lymphoma, December 2017, Taylor & Francis,
DOI: 10.1080/10428194.2017.1406090.
You can read the full text:
Contributors
The following have contributed to this page
