Endometrial hyperplasia treatment

What is it about?

The primary antihyperglycemic effect of metformin, an oral biguanide and a preferred treatment for type-2 diabetes, is caused by the suppression of hepatic glucose production. Metformin which activates AMP-activated protein kinase (AMPK) and reduces protein synthesis and cell proliferation via suppression of the mTOR. Metformin also increases insulin sensitivity and cellular glucose uptake and thus decreases circulating insulin levels; insulin and insulin-like growth factor (IGF)-1 are known to increase cell proliferation We examined metformin effect both histopathologically and genetically for endometrial hyperplasia treatment

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Why is it important?

The data indicate that metformin reduces estrogen-induced EH in rats, via activation of the caspase-dependent mitochondrial apoptotic pathway, to the same degree as progesterone.