Efficacy of two oximes during inhalation of sarin vapor

What is it about?

Protection efficacy of two treatments evaluated during inhalation of a nerve agent vapor (sarin) in simulated real scenario in vivo. Majority of the animals either became moribund or died within 1–2 min during exposure to multifold-lethal concentrations of sarin vapor. Protection indices were determined by exposing to sarin vapor in two sessions, 1 min exposure followed by treatments with or without the treatments and atropine and again exposed for remaining 14 min. Protection offered by a new compound (HNK-102) was found to be four folds higher compared to the available standard compound (2-PAM) in the same toxic environment.

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Why is it important?

To the best of our knowledge, this the first study in which protection efficacy of two antidotes was evaluated in the same sarin vapor intoxicated environment, very close to simulated real scenario condition. Our findings confirmed that the new compound (HNK-102) is far more superior compared to that of available standard antidote (2-PAM). Following this novel approach, a number of other related information were also gathered e.g. It was confirmed that during inhalation of sarin vapor, treatment with atropine alone was either ineffective or increased the toxicity. We strongly recommend to use the same method for similar type of comparative evaluation studies.

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