What is it about?
Growing of Burkholderia pseudomallei as biofilm exhibited resistance to conventional antibiotics. We have shown that D-LL-31 can enhance the bactericidal activity of ceftazidime to kill Burkholderia pseudomallei under-biofilm stimulating condition.
Featured Image
Why is it important?
We found that D-LL-31 has a strong killing effect on B. pseudomallei under biofilm-inducing conditions and enhanced synergistically the effect of CAZ. It also disrupted the biofilm matrix of B. pseudomallei while being nontoxic to human red blood cells.
Perspectives
D-LL-31 should be further developed as a novel antibiofilm agent in single therapy or used as an adjunctive agent to enhance the efficacy of current antibiotics for the treatment of melioidosis.
Dr Saharut Wongkaewkhiaw
Khon Kaen University
Read the Original
This page is a summary of: D-LL-31 in combination with ceftazidime synergistically enhances bactericidal activity and biofilm destruction in Burkholderia pseudomallei, Biofouling, May 2019, Taylor & Francis,
DOI: 10.1080/08927014.2019.1632835.
You can read the full text:
Contributors
The following have contributed to this page
