What is it about?
Cathelicidin treatment attenuated kidney injury as evidenced by lower kidney injury scores, 8-OHdG-positive cells, collagen deposition, and reversion of hyperoxia-induced M1/ M2 macrophage polarization.
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Why is it important?
This study demonstrated the therapeutic potential of cathelicidin in protecting against hyperoxia-induced kidney injury. This study also revealed that cathelicidin does not exert adverse effects on normal neonatal kidney development. Currently, no effective therapy is clinically available to prevent hyperoxia- induced kidney injury. Cathelicidin therapy may provide a novel strategy for preventing hyperoxia-induced kidney injury.
Perspectives
This study revealed that cathelicidin does not exert adverse effects on normal neonatal kidney development. Currently, no effective therapy is clinically available to prevent hyperoxia-induced kidney injury. Cathelicidin therapy may provide a novel strategy for preventing hyperoxia-induced kidney injury.
Professor Chung-Ming Chen
Taipei Medical University
Read the Original
This page is a summary of: Cathelicidin attenuates hyperoxia-induced kidney injury in newborn rats, Renal Failure, January 2019, Taylor & Francis,
DOI: 10.1080/0886022x.2019.1651741.
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