What is it about?
This study describes the biopsy work-up done to reach a diagnosis of AL amyloidosis and establish the extent of organ involvement
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Why is it important?
It demonstrates that patients undergo unnecessary organ biopsies when the diagnosis of AL amyloidosis can be achieved using more accessible tissue source (bone marrow, fat, lip....), while extent of organ involvement can follow consensus criteria in most patients
Perspectives
The study emphasizes that there is still a way to go with having enough awareness and recognition for amyloidosis in the differential diagnosis of characteristic organ dysfunctions (diastolic heart failure, nephrotic syndrome, hepatopathy, unexplained GI symptoms, peripheral and autonomic neuropathy, myopathy, macroglossia and others). Serum free light chain assay and other monoclonal studies are excellent screening tools and should be utilized more frequently
Eli Muchtar
Mayo Foundation
Read the Original
This page is a summary of: Overuse of organ biopsies in immunoglobulin light chain amyloidosis (AL): the consequence of failure of early recognition, Annals of Medicine, March 2017, Taylor & Francis,
DOI: 10.1080/07853890.2017.1304649.
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