What is it about?
inhibitors were screened by computational method like docking and molecular dynamics simulation studies and activity was tested in lab by procuring the inhibitors commercially and finally reporting its activity as well as reporting the role of nad synthase protein in leishmania parasite for its survival.
Featured Image
Why is it important?
in bihar, INDIA leishmaniasis is a life threatening disease. there are only four drugs to treat the disease. those drugs are going into resistance. there is an urgent need to find out potential inhibitor against a new potential target (which is very much essential for the parasite survival) . thus this study will help to find out an alternate approach for the treatment of leishmaniasis either as monotherapy or as combination therapy in drug resistant cases of leishmaniasis.
Perspectives
this study will open a new door to understand the parasite nature and behaviour and the importance of the nad synstase protein for the survival of the parasite inside human host. secondly it will motivate other synthetic chemist and drug discovery researcher, pharmaceutical chemist or biologist to find out a formulation of the screened inhibitors and synthetically derive some more potent analogues of the inhibitors so as to reach to the suffering patients and help in eradication of the life threatening disease and give a new ray of hope to the humanity. not only leishmaniasis, the target nad synthase can be a potential target for other pathogenic disease also and the same inhibitors can be used against many pathogenic diseases also.
Haraprasad Mandal
Read the Original
This page is a summary of: Validation of NAD synthase inhibitors for inhibiting the cell viability of Leishmania donovani: In silico and in vitro approach, Journal of Biomolecular Structure and Dynamics, December 2018, Taylor & Francis,
DOI: 10.1080/07391102.2018.1552199.
You can read the full text:
Resources
Contributors
The following have contributed to this page
