What is it about?
Artesunate is proven to have potential anti-proliferative activities, but its instability and poor aqueous solubility limit its application as an anti-cancer drug. The present study was undertaken to develop coaxial electrospraying as a novel technique for fabricating nanoscale drug delivery systems of artesunate as the core–shell nanostructures.
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Why is it important?
The core–shell nanoparticles were fabricated with coaxial electrospraying and their formation mechanisms were examined. The present results suggest that the core–shell nanoparticles containing PLGA and chitosan have a potential as carriers in the anticancer drug therapy of artesunate.
Perspectives
Comparing to the other commonly used methods, coaxial electrospraying is a single-step technique to prepare the artesunate-loaded nanoparticles with a PLGA–chitosan core–shell structure.
Hoang Nhan Ho
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This page is a summary of: Development of electrosprayed artesunate-loaded core–shell nanoparticles, Drug Development and Industrial Pharmacy, March 2017, Taylor & Francis,
DOI: 10.1080/03639045.2017.1300163.
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