What is it about?
We introduced a comparative simulation study that has different model structures and prior distributions in the continual reassessment method (CRM). In order to understand the effect of model structures and prior distributions, a real life story and nine scenarios are implemented.
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Why is it important?
It is important to understand the fundamental of the CRM. Using the different model structures and prior distributions can cause different results based on the scenario.
Perspectives
The dose–response methods to be selected in the application of the statistical method of the clinical trials should carefully investigated. Small changes in targeted toxicity rates can be dangerous for patients treated in that dose level.
EFEHAN ULAS
Cankiri Karatekin Universitesi
Read the Original
This page is a summary of: Impact of different model structure and prior distribution in continual reassessment method, Communications in Statistics - Simulation and Computation, September 2018, Taylor & Francis,
DOI: 10.1080/03610918.2018.1476698.
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