Molecular variant of a virulent Marek’s disease virus field strain recently isolated from japan

What is it about?

The results revealed high similarity between the field isolates, vv and vv+ strains of MDV from the USA and China. Several point mutations in the nucleotide sequence of the field isolates and their deduced amino acid sequences were detected in those genes. The present molecular analyses indicated that nucleotide and amino acid changes could be valuable criteria for differentiation and determination of the pathogenicity and oncogenicity of MDVs

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Why is it important?

the results suggest that development of a new vaccine must be considered to overcome this devastating avian oncogenic viral disease.

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