What is it about?
We determined the apoptotic effect caused by the most used vaccines in local production on the bursa of Fabricius cells and the correlation with histological changes. In this study, it was demonstrated that apoptosis levels in the vaccinated groups were higher than those observed in the non-vaccinated birds
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Why is it important?
In conclusion vaccination with strains of infectious bursitis or Gumboro disease produces an increase in the number of apoptotic cells in the medullar areas of the bursa of Fabricius together with its enlargement and development of an inflammatory phenomenon.
Perspectives
Finding that injury at the cellular level of the bursa is significant, warning must be given about the use of these strains and new strategies of vaccination treatment probably suggested, such as recombinant vaccines, in ovo vaccination or other ways in which the risk of harm and/or reversion is diminished
Marcelo Killian
Universidad de Buenos Aires
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This page is a summary of: Induction of apoptosis in the bursa of Fabricius by vaccination against Gumboro disease, Avian Pathology, June 2017, Taylor & Francis,
DOI: 10.1080/03079457.2017.1322684.
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