Genetic variants in BDNF ( rs6265 and rs11030119 ) and stroke susceptibility

What is it about?

This paper presents a case-control study examining the association between BDNF gene polymorphisms (rs6265 and rs11030119) and susceptibility to stroke in a South Indian population. The study investigates how these genetic variants, known to influence neuroplasticity and neuronal survival, may contribute to individual differences in stroke risk. By analyzing genotype and allele frequencies in stroke patients and healthy controls, the research provides region-specific insights into the genetic architecture of stroke and highlights the potential role of BDNF polymorphisms as biomarkers for stroke predisposition in South India.

Featured Image

Photo by Shawn Day on Unsplash

Photo by Shawn Day on Unsplash

Why is it important?

Stroke is a major cause of disability and death, particularly in low- and middle-income regions like South India, where genetic risk factors are not well-characterized. This paper is important because it provides valuable evidence on the potential role of BDNF (rs6265 and rs11030119) polymorphisms in stroke susceptibility, offering region-specific genetic insights that could inform risk prediction and prevention strategies. The findings contribute to the growing field of neurogenetics and support the development of personalized approaches to stroke management in diverse populations.

Perspectives