Development and characterization of morin hydrate-loaded NLC

What is it about?

The aim of this study was to prepare and characterize oral delivery of morin hydrate-loaded micellar nanocarriers using Pluronic P127 and Pluronic F123 for the effective management of Alzheimer’s disease.

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Why is it important?

After administration of formulation brain and blood drug concentration were found to be highest for optimized morin hydrate-loaded micellar nanocarriers as compared to plain morin hydrate. Significant (p<0.05) reduction in assessed pharmacodynamic parameters was observed after administration of morin hydrate-loaded micellar nanocarriers as compared to disease control group. Chronic treatment with morin-loaded micelles significantly increased the memory in AlCl3 induced Alzheimer’s disease in Wistar rats.

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