What is it about?
Xanthone is a potent anti-inflammatory and antitumor molecule of natural source, it was encapsulated in a 90 % into an oil-in-water emulsion to preserve their properties and study the release kinetic. The release was dependent on the concentration of xanthone where at high concentrations, pi-stacking interactions between xanthone preclude the release .
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Why is it important?
We observed that the chemical structure of xanthone has a strong effect on the release kinetic. At high concentrations of xanthone, the release is retarded because pi-stacking are strong inside the droplets and preclude the release. At low concentrations, however, pi-stacking interactions are weak and the release of xanthone is faster in comparison with high concentrations. Besides it was shown that the macromolecules used to stabilize the emulsion allow to tailor the release according to the external conditions. In this sense, at low concentrations of xanthone and at intestine simulated conditions the release is faster that at acidic conditions.
Perspectives
I think the present work is a contribution to other colleagues who are researching on encapsulation and controlled release of different molecules. The chemical structure of the molecules must be taken into account and pi-stacking intermolecular interactions as well, in order to be able to analyse the results.
Yanina Martinez
Comision Nacional de Energia Atomica
Read the Original
This page is a summary of: Oil-in-water emulsion development for the encapsulation and sustained release of xanthone, Journal of Dispersion Science and Technology, May 2019, Taylor & Francis,
DOI: 10.1080/01932691.2019.1578663.
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