Toxicokinetic and toxic comparisons of oxiracetam and (S)-oxiracetam

What is it about?

This work characterizes the toxicokinetics and toxicity of oxiracetam and (S)-oxiracetam in an acute study and a 13-week repeated oral dose study in beagle dogs. The results suggest that (S)-oxiracetam could be a superior medication compared to racemic oxiracetam.

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Why is it important?

Observations on the dose-exposure relationship in dogs are also provided. These findings may provide further insight into the toxicological evaluation of chiral drugs.