What is it about?
The purpose of this study was to identify the prevalence of risk factors for QT interval prolongation; QT prolonging medications; drug–drug interactions; their predictors; and torsades de pointes risks of drugs.
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Why is it important?
This study highlighted the high prevalence of risk factors for QT prolongation during hospitalization. The majority of patients presented with multiple risk factors for QT prolongation in CCUs. Moreover, there was a high prevalence of certain drug classes that carried the risk of TdP. All of these factors may lead to fatal consequences and ultimately affect the patients’ safety. Therefore, QTc interval measurements should be performed on routine basis particularly before or after starting a QT prolonging drug. Further research is needed to explore the extent and magnitude of drug-induced QTc prolongation in such a population.
Perspectives
This is the first study on this topic in developing country like Pakistan. The results can be applied to similar settings in developing countries for the purpose to rationalize medication therapy.
Dr Mohammad Ismail
University of Peshawar
Read the Original
This page is a summary of: High prevalence of the risk factors for QT interval prolongation and associated drug–drug interactions in coronary care units, Postgraduate Medicine, September 2018, Taylor & Francis,
DOI: 10.1080/00325481.2018.1516106.
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