What is it about?
While it is well known that the gut microbiome influences colorectal cancer, how the host's genetics dictate this relationship remains unclear. This study demonstrates that a specific genetic variant in the intestinal transporter SLC22A4 (OCTN1) promotes colorectal cancer, directly supporting the presence and survival of a tumor-promoting bacterium, creating an environment that favors the progression of colorectal cancer.
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This page is a summary of: Genetic variants of the transporter SLC22A4 affect the abundance and survival of
Fusobacterium nucleatum
in colorectal cancer, Gut Microbes, June 2026, Taylor & Francis,
DOI: 10.1080/19490976.2026.2681818.
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