What is it about?

The participants to the exercise predictions were given a set of molecular structures and invited to assess the hazard posed by them using read-across on similar substances. The exercise was based on three endpoints: mutagenicity, bio-concentration factor and fish acute toxicity. The reports of the anonymous responses were analyzed in terms of repeatability, justification, rationale used.

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Why is it important?

The interesting aspect of this exercise is the justification behind the answers more than the final prediction in itself. Which tools were used? How did the approach selected affect the final answer? The results show low consistency of the answers, and open a doubt about the repeatability of those assessments.

Perspectives

The results show the importance of developing tools to help expert assessments.

Prof Giuseppina Carla Gini
Politecnico di Milano

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This page is a summary of: Results of a round-robin exercise on read-across, SAR and QSAR in Environmental Research, May 2016, Taylor & Francis, DOI: 10.1080/1062936x.2016.1178171.
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