What is it about?
In our new study, we show that increasing the protein JAG1 in muscles of mouse models of Duchenne muscular dystrophy (DMD) leads to bigger and stronger muscles with less scarring. Our findings provide important insights for developing therapies that target the Notch pathway in muscular dystrophies.
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Photo by Lucas Vasques on Unsplash
Why is it important?
DMD has no cure, and current treatments only slow disease progression. By showing that muscles without dystrophin grow bigger by boosting JAG1, our work sums to different scientific efforts to develop complementary therapies to DMD.
Perspectives
There is a lot to learn from genetic modifiers in muscular dystrophies. I hope this article will lead to novel efforts to improve the lives of DMD patients.
Felipe de Souza Leite
Children's Hospital Boston
Read the Original
This page is a summary of: Muscle-specific increased expression of
JAG1
improves the skeletal muscle phenotype in dystrophin-deficient mice, Proceedings of the National Academy of Sciences, September 2025, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.2506437122.
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