What is it about?
Our brains are remarkably good at recognizing patterns, generalizing to new situations, and filtering important signals from background noise while using very little energy. This study identifies that utilizing canonical cortical circuits enables selective amplification of important signals, generalization to new situations, and resilience to noise. We translated this principle directly into neuromorphic hardware, specialized chips that mimic how real brains process and represent information. The circuit, built on the incorporation of four inhibitory neuron types to amplify relevant inputs and suppress distractions. Implemented on a state-of-the-art neuromorphic chip (IBM TrueNorth), the hardware reproduced brain-like selectivity and scaled efficiently with network size. When used as a biologically inspired preprocessing stage for a Vision Transformer the system learned faster, required less data, and stayed robust to unfamiliar or noisy images, improving accuracy by up to 20 percent without extra data or architectural changes. These results show how a brain-derived computation can be used in silicon to create more efficient, noise-resilient, and generalizable artificial intelligence.
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Why is it important?
Modern AI is powerful but data-hungry and energy-intensive, with growth that is increasingly unsustainable. Neuromorphic chips offer an energy-efficient alternative because they compute only when needed, operate asynchronously without a global clock, and co-localize memory and computation. This event-driven, co-localized design mirrors how real neurons process information, greatly reducing power use. By embedding brain-inspired circuits into such hardware and coupling them to existing AI models, we provide a practical route toward sustainable intelligence. This work illustrates how biologically grounded circuit motifs make modern AI more efficient and environmentally responsible. Using our neuromorphic prefilter for Transformer analysis improved generalization in tasks such as zero-shot digit recognition and nighttime scene understanding by efficiently steering learning toward the most informative features. Because this prefilter functions as a plug-and-play front end that does not require retraining of the main network, it integrates seamlessly with existing methods for edge devices, robotics, and biomedical applications. Together, these results show how brain-inspired computing principles can power the next generation of intelligent and sustainable technologies.
Perspectives
We translated a brain computational primitive into neuromorphic hardware, showing that core cortical computation can be physically realized in event-driven, brain-like silicon circuits. Used as a prefilter for modern AI architectures, this circuit improved robustness and reduced training demands, demonstrating that evolution’s design principles can directly inform next-generation machine intelligence.
Gordon Fishell
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This page is a summary of: Biologically grounded neocortex computational primitives implemented on neuromorphic hardware improve vision transformer performance, Proceedings of the National Academy of Sciences, October 2025, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.2504164122.
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