What is it about?
Proteasomes act as the cell’s cleanup system. This study shows that having more 26S and 30S proteasomes helps cells remove harmful protein clumps that can lead to diseases such as Alzheimer’s. Strengthening this protein-disposal machinery may help prevent or slow the progression of protein-related disorders.
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Why is it important?
This study discovered a protein that helps control the balance between different types of proteasomes in mammals. It also showed that proteasome assembly in mammals may work differently from yeast, revealing a new way cells manage protein quality. Importantly, increasing the levels of 26S and 30S proteasomes reduced harmful protein buildup in a mouse model of tau-related disease. These results suggest that targeting proteasome assembly, not just its activity, may offer a new approach for treating neurodegenerative diseases such as Alzheimer’s.
Perspectives
Until now, most studies on proteasome assembly regulation have been done in yeast. This publication highlights that proteasome assembly may differ between yeast and mammals. It also shows that adjusting proteasome assembly, not just its activity, can help reduce protein-related diseases. This work emphasizes the importance of proteasome assembly in maintaining cellular health and points to new strategies for combating proteinopathies.
Yong-Keun Jung
School of Biological Sciences, Seoul National University, Seoul 08826, Korea.
Read the Original
This page is a summary of: More 26S and 30S proteasomes are beneficial in proteinopathy, Proceedings of the National Academy of Sciences, September 2025, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.2422570122.
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