What is it about?
How do dynamical forces generated by tissue movement affect organ morphology changes during embryonic development? Using Kupffer’s vesicle in zebrafish embryo as a model organ we showed that dynamical forces produce shape changes in a developing organ.
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Why is it important?
Since we demonstrated that self-generated dynamical forces help govern the shape and development of organs, it suggests that new, understudied mechanisms (cell motility, tissue viscosity generated by cell-cell interactions in the surrounding tissue) might be important in different types of congenital disease.
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This page is a summary of: Dynamic forces drive cell and organ morphology changes during embryonic development, Proceedings of the National Academy of Sciences, July 2025, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.2418111122.
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