What is it about?
Tissue oxygenation can be detected via endogenously produced fluorescence signals. Our research demonstrates that these signals can effectively highlight diseased tissue with compromised vasculature, such as tumors, providing a novel contrast mechanism for differentiating between normal and malignant tissue.
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Why is it important?
This innovative technique called Pressure Enhanced Sensing of Tissue Oxygen or PRESTO, holds promise for improving cancer detection and diagnosis, as well as advancing understanding and treatment of various diseases characterized by compromised vascular reactivity. With demonstrated efficacy across multiple tumor lines and potential applications beyond oncology, our work represents a significant conceptual breakthrough in in vivo contrast creation.
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This page is a summary of: Pressure-enhanced sensing of tissue oxygenation via endogenous porphyrin: Implications for dynamic visualization of cancer in surgery, Proceedings of the National Academy of Sciences, August 2024, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.2405628121.
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