What is it about?
Iron regulatory protein 2 contributes to antimicrobial immunity by preserving lysosomal function in macrophages.
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Why is it important?
Colorectal cancer and Crohn’s disease patients develop pyogenic liver abscesses due to failures of immune cells to fight off bacterial infections.
Perspectives
we show that Iron regulatory protein 2 affects lysosome biosynthesis and acidification through hypoxia-inducible factor 2 and its target gene lactate dehydrogenase A in macrophages. Lactic acid production or hypoxia-inducible factor 2 inhibitors are potential therapeutical treatments for inflammatory bowel disease with or without pyogenic liver abscesses.
Kuanyu Li
Nanjing University
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This page is a summary of: Iron regulatory protein 2 contributes to antimicrobial immunity by preserving lysosomal function in macrophages, Proceedings of the National Academy of Sciences, July 2024, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.2321929121.
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