What is it about?
In sickle cell disease, low oxygen causes stiffening of the red blood cells and reduced blood flow. In this study, we measured the mechanical properties of red blood cells from individuals with sickle cell disease. We found that stiffened red blood cells could be found in conditions that would be relevant throughout the body.
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Why is it important?
This measurement could be used to assess new therapies for sickle cell disease including gene therapy.
Read the Original
This page is a summary of: High-throughput quantification of red blood cell deformability and oxygen saturation to probe mechanisms of sickle cell disease, Proceedings of the National Academy of Sciences, November 2023, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.2313755120.
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