RNA-binding motif protein 10 inactivates c-Myc by partnering with ribosomal proteins uL18 and uL5

Hyemin Lee; Ji Hoon Jung; Hyun Min Ko; Heewon Park; Allyson M. Segall; Roger L. Sheffmaker; Jieqiong Wang; Wesley D. Frey; Nathan Pham; Yongbo Wang; Yiwei Zhang; James G. Jackson; Shelya X. Zeng; Hua Lu

doi:10.1073/pnas.2308292120

What is it about?

This study reveals a novel function of a known anti-cancer protein in suppressing lung cancer growth by inhibiting an important oncoprotein called "c-Myc" via a unique way.

Why is it important?

This known anti-cancer protein is called "RBM10" that stands for RNA binding protein 10, a member of a big family in our human body. Its gene is often altered in human lung cancers as well as other types of cancers to lose its ability to suppress cancer cell growth. This study also found out that one of the altered protein products can promote lung cancer growth, instead of suppressing cancer growth. Thus, this finding along with the findings as mentioned above is clinically significant.

Perspectives

Our findings also suggest a new potential target for developing anti-cancer therapeutic approaches against lung cancers that harbor this mutated RMB10 protein.
Hua Lu
Tulane University

This page is a summary of: RNA-binding motif protein 10 inactivates c-Myc by partnering with ribosomal proteins uL18 and uL5, Proceedings of the National Academy of Sciences, November 2023, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.2308292120.
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RNA-binding motif protein 10 inactivates c-Myc by partnering with ribosomal proteins uL18 and uL5
Lung cancer is one of the most common cancers and the leading cause of cancer-related deaths in the world. Understanding the molecular mechanisms underlying lung cancer growth and progression is critical for developing early diagnosis and strategies for cancer prevention and therapy. This study reveals that the tumor suppressor RBM10 works with ribosomal proteins and acts to inhibit the oncogenic activity of c-Myc, whereas a lung cancer–derived RMB10 mutant fails to do so; instead, it promotes lung cancer growth. These findings not only unveil a mechanism underlying the action of this tumor suppressor in inhibiting lung cancer growth but also suggest a pathway for developing potential combinatorial therapies against malignant lung cancer.

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Hua Lu
Tulane University

RNA-binding motif protein 10 inactivates c-Myc by partnering with ribosomal proteins uL18 and uL5

What is it about?

Why is it important?

Perspectives

Resources