What is it about?

We have found that a protein called PHD3, which is induced by fasting, plays a role in regulating the production of glucose by the liver. PHD3 works by hydroxylation of another protein called CRTC2, which then activates genes involved in producing glucose.

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Why is it important?

Our findings offer insights into the molecular mechanisms linking protein hydroxylation to gluconeogenesis and may have therapeutic potential for treating excessive gluconeogenesis, hyperglycemia, and type 2 diabetes.


This is my major Ph.D. project, and I have dedicated amount of time to it. I hope that the article's findings will provide new avenues for researchers to explore the pathogenesis of type 2 diabetes.

Yaqian Xue
Shanghai Institute of Nutrition and Health

Read the Original

This page is a summary of: Proline hydroxylation of CREB-regulated transcriptional coactivator 2 controls hepatic glucose metabolism, Proceedings of the National Academy of Sciences, May 2023, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.2219419120.
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