What is it about?
Regulatory T cell (Treg) therapy can control unwanted immune responses. We investigated whether too much stimulation could have negative effects.
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Why is it important?
There is a lot of interest in using genetic engineering to make the effects of Tregs more potent, this work shows that too much activity leading to a state known as "exhaustion" could have negative effects on Treg function.
Perspectives
This work was made possible by fantastic collaborations and used an extreme situation to create a "benchmark" of Treg exhaustion. The datasets in this paper can now be used as a reference to study Treg exhaustion in other contexts.
Megan Levings
University of British Columbia
Read the Original
This page is a summary of: Tonic-signaling chimeric antigen receptors drive human regulatory T cell exhaustion, Proceedings of the National Academy of Sciences, March 2023, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.2219086120.
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