What is it about?
Changes in the firing parameters of entopeduncular nucleus parvalbumin neurons, including firing rate and firing pattern, are associated with changes in parkinsonian motor dysfunction. When the firing rate and firing pattern of entopeduncular nucleus parvalbumin neurons are altered simultaneously, the regularized firing pattern of entopeduncular nucleus parvalbumin neurons is more critical for improving parkinsonism-associated motor dysfunction.
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Why is it important?
Our findings show that although a reduced firing rate and more regular firing pattern of entopeduncular nucleus parvalbumin neurons correlated with the amelioration of parkinsonism-associated motor dysfunction, the firing pattern appears to be more critical in this context.
Perspectives
Targeting H2R and its downstream HCN2 channel in parvalbumin neurons of the entopeduncular nucleus and H3R in subthalamic glutamatergic neurons projecting to the EPN may provide potential therapeutic strategies for the clinical treatment of Parkinsonism-associated motor dysfunction.
Prof. Qian-Xing Zhuang
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This page is a summary of: Ameliorating parkinsonian motor dysfunction by targeting histamine receptors in entopeduncular nucleus–thalamus circuitry, Proceedings of the National Academy of Sciences, April 2023, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.2216247120.
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