What is it about?
Discovery of two master genes that control the production of progenitors essential for the development of cells critical for maintaining ionic balance in the chambers of the inner ear. Deficit in the function of these progenitors result in deafness .
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Why is it important?
Human hearing loss leads to physical and social difficulties. The discovery of these SOXE genes in hearing opens the way to identify mechanisms of hearing function and potential target genes to understand. congenital deafness.
Perspectives
In trying to understand why mutations in these master genes caused deafness we found unexpected mechanisms that went against dogma. By using different approaches- genetics, mouse models, biochemistry, single cell analyses and developmental biology, we learnt a lot about how genes can control the ionic composition of the fluid in the inner ear that is so important for hearing. We hope that readers will find the paper interesting
Kathryn Cheah
University of Hong Kong
Read the Original
This page is a summary of: SOX9 and SOX10 control fluid homeostasis in the inner ear for hearing through independent and cooperative mechanisms, Proceedings of the National Academy of Sciences, November 2022, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.2122121119.
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