What is it about?

RNA is an important type of biomolecules in the cell nucleus, contributing to ordered gene expression. We show that the previously unknown nuclear RNA PIRAT contributes to misguided immune gene expression in blood cells from patients with severe COVID-19.

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Why is it important?

Our findings show that the less PIRAT RNA is produced, the more of immune-mediators promoting severe COVID-19 are generated. This suggests a negative relationship between the amount of PIRAT RNA produced in human immune cells and severe COVID-19 outcomes.


We believe that artificial manipulation of the expression of PIRAT could interfere with severe disease progression, not only during COVID-19, but also in the context of other infectious diseases.

Leon Schulte
Philipps-Universitat Marburg

Read the Original

This page is a summary of: Single-cell RNA sequencing uncovers the nuclear decoy lincRNA PIRAT as a regulator of systemic monocyte immunity during COVID-19, Proceedings of the National Academy of Sciences, August 2022, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.2120680119.
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