What is it about?
We associate discomfort with information that coincide with the discomfort to form a memory, and use that memory to guide future behavior in order to avoid that discomfort. This aversive associative learning is a fundamental feature of animal learning and behavior. By studying a tiny roundworm, we identify nerve cells and signals that are important for this learning.
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Why is it important?
The nerve signal identified in this work is also present in higher animals, including mammals and human. Understanding how this nerve signal regulates memory contributes to a deeper insight into the mechanism of learning and memory related to stress.
Perspectives
Our study demonstrates the usefulness of a simpler organism in dissecting the mechanisms of memory, learning and cognition.
Chun-Liang Pan
National Taiwan University
Read the Original
This page is a summary of: A serotonergic circuit regulates aversive associative learning under mitochondrial stress in
C. elegans, Proceedings of the National Academy of Sciences, March 2022, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.2115533119.
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