What is it about?
This paper is about the metabolic state shifted in hypoxic M. tuberculosis, an etiological agent of tuberculosis, required to achieve the drug tolerance and growth arrest.
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Why is it important?
Current TB treatment is not ideal due to less killing effects on M. tuberculosis in a latent state. This study will provide the therapeutic options to boost current TB treatment strategy by improving the mass eradication of M. tuberculosis population including ones in a latent state.
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This page is a summary of: Phosphoenolpyruvate depletion mediates both growth arrest and drug tolerance of
Mycobacterium tuberculosis
in hypoxia, Proceedings of the National Academy of Sciences, August 2021, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.2105800118.
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