What is it about?
Secondary nosocomial infections typically worsen outcomes in patients recovering from septic shock. We have shown the role of circulating mitochondrial N-formyl peptides (mtFPs) in the development of secondary infection in patients with septic shock who survive their early hyperinflammatory phase. We have focused on neutrophil function changes.
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Why is it important?
Our findings show that circulating mtFPs inhibit neutrophil migration from the circulation to secondarily inoculated sites by occupying formyl peptide receptor-1 (FPR1) on the neutrophil membrane, thus resulting in the progression from local bacterial inoculation to secondary infection. We suggest that immunotherapy desensitizing and/or eliminating circulating mtFPs, before secondary infection can occur, may be a therapeutic strategy to reduce the development of secondary infection in patients recovering from septic shock.
Perspectives
I hope that this article will help develop new treatments to improve clinical outcomes in patients with septic shock. I sincerely thank the co-authors.
Woon Yong Kwon
Seoul National University
Read the Original
This page is a summary of: Circulating mitochondrial
N
-formyl peptides contribute to secondary nosocomial infection in patients with septic shock, Proceedings of the National Academy of Sciences, April 2021, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.2018538118.
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